Akt-dependent activation of Erk by cyclin D1b contributes to cell invasiveness and tumorigenicity
نویسندگان
چکیده
منابع مشابه
Akt-dependent activation of Erk by cyclin D1b contributes to cell invasiveness and tumorigenicity.
A total of two major isoforms, cyclin D1a and cyclin D1b, are generated from the human cyclin D1 gene by alternative splicing. Cyclin D1b is scarcely expressed in normal tissues; however, it is expressed at a high frequency in certain types of cancerous tissue. The present authors previously constructed cyclin D1b transgenic (Tg) mice and identified rectal tumors, including adenocarcinoma and s...
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ژورنال
عنوان ژورنال: Oncology Letters
سال: 2016
ISSN: 1792-1074,1792-1082
DOI: 10.3892/ol.2016.5286